Wednesday 18th May 2022
14.15-14.30 Opening Ceremony
SESSION 1. PROTEIN INTERACTIONS WITH MACROMOLECULES
Chairs: Louise Gourlay (Università di Milano), Valerio Marino (Università di Verona)
14.30-15.00 Adeline Goulet, CNRS Marseille, “Diversity of CRISPR-Cas9 inhibition mechanisms: the tip of an iceberg?"
15.00-15.30 Roberto Contestabile, Università di Roma “La Sapienza”, “Specific and non-specific protein-DNA interactions in transcriptional regulation mediated by MocR-like PLP-dependent factors”
15.30-16.00 Linda Celeste Montemiglio, C.N.R., Istituto di Biologia e Patologia Molecolari, Roma, “Insights on the role of the CD71 iron gate from the cryoEM structure of its complex with ferritin”.
16.00-16.30 Coffee break
Chairs: Nadia Raffaelli (Università Politecnica delle Marche), Riccardo Miggiano (Università del Piemonte Orientale)
16.30-17.00 Stefano Ricagno, Università di Milano, “Ex-vivo structural biology: new insights on systemic amyloidosis” “
17.00-17.30 Loredano Pollegioni, Università dell'Insubria, “Ligand-binding properties of human D-amino acid oxidase: regulation of brain D-serine levels”
17.30-18.00 Stefano Bettati, Università di Parma, “Chasing new targets to fight antimicrobial resistance: interaction of the Staphylococcus aureus hemophore IsdB with human hemoglobin”.
18,00-18.20 Sergio Braglia, PerkinElmer Italia, Milano, “ALPHA and HTRF: homogeneous and quantitative proximity assays to assess protein-protein interaction in pharmacological research”
18.30-19.30 Poster session
19.30 Cocktail
20:15-21:15 Round tables organized by Young Researchers on the following themes:
1. Gender issue in science.
Chairs: Francesca Maffioli (University of Paris), Mariafrancesca Scalise (Università della Calabria), Elisa Maffioli (Università di Milano)
2. Research and Career Skills.
Chairs: Stefano Gianni (Università di Roma, “La Sapienza”), Matteo Becatti (Università di Firenze), Chiara Giacomelli (Università di Pisa)
3. How skills become technologies.
Chairs: Carlo Bonadonna (Fondazione UNIMI), Miggiano Riccardo (Università del Piemonte Orientale), Francesco Marchesani (Università di Parma)
Thursday 19th May 2022
SESSION 2. PROTEIN INTERACTION WITH SMALL LIGANDS
Chairs: Serena Faggiano (Università di Parma), Francesco Marchesani (Università di Parma)
09.00-09.30 Claudiu Supuran, Università di Firenze, “Carbonic anhydrases and their interaction with inhibitors and activators”
09.30-10.00 Roberta Moschini, Università di Pisa, “NADP+/NADPH in human carbonyl reductase 1: from co-reagent to prosthetic group.”
10.00-10.30 Francesca Spyrakis, Università di Torino, “Looking for broad-spectrum inhibitors targeting carbapenemases”
10:30-10:50 Maria Rita Bertoldi, Università di Verona, “The structural characterization of human aromatic amino acid decarboxylase provides the molecular basis for prediction of severity in AADC deficiency”
10.50-11.15 Coffee break
Chairs: Barbara Cellini (Università di Perugia), Chiara Giacomelli (Università di Pisa)
11.15-11.45 Paolo Pelosi, Austrian Institute of Technology, "Reverse chemical ecology: from carrier proteins to pheromones"
11.45-12.15 Krishna Persaud, University of Manchester, “Advances in Odorant Binding Protein Biosensors”
12.15-12.45 Silvia Garavaglia, Università del Piemonte Orientale, “Targeting human aldehyde dehydrogenase 1A3 in gliomas: drugs and diagnostics development"
12.45-13.15 Antonio Chaves, Università di Milano, "NF-Y ligand fragment search through macromolecular crystallography"
13.15-14.00 Lunch
14.00-15.00 Poster session
SESSION 3. CASE STUDIES FROM PHD STUDENTS
Chairs: Maria Grazia Tozzi (Università di Pisa), Mariafrancesca Scalise (Università della Calabria)
15.00-16.15 5 speakers (12 min)
16.15-16.45 coffee break
16.45-18.00 5 speakers (12 min)
18.00-19.00 Poster session
20.30 Dinner
Friday 20th May 2022
SESSION 4. METHODS AND MODELS FOR THE CHARACTERIZATION OF PROTEIN INTERACTION
Chairs: Antonio Chaves (Università di Milano), Martina Buonanno (Istituto di Bioistrutture e Bioimmagini - CNR)
09.00-09.30 Gabriele Cruciani, Università di Perugia “BioGPS, a virtual journey through the universe of proteins”
9.30-10.00 Silvio Tosatto, Università di Padova, “Deciphering the structural features of linear interacting peptides in proteins
10.00-10.20 Mario Armelao, SCIEX, “A way to maximize performance for Protein ID and Quant”
10.20-10.50 coffee break
Chairs: Serena Rinaldo (Università di Roma “La Sapienza”), Matteo Becatti (Università di Firenze)
10.50-11.20 Martin Weik, ESRF, Grenoble, “Structure and dynamics of light-sensitive proteins using time-resolved X-ray scattering and crystallography at synchrotrons and XFELs”
11.20-11.50 Alessandro Paciaroni, Università di Perugia, “Small molecule inhibitors of the SARS-CoV-2 main protease dimerization as potential antivirals”.
11.50-12.20 Leila Birolo, Università di Napoli, “Ancient proteins: from identification to characterization”
12.20-12.50 Elisa Maffioli, Università di Milano, " SILAC-based quantitative phosphoproteomic analysis on the effect of binding of CCL3L1 to the atypical chemokine receptor ACKR2".
12.50 Concluding remarks
