Wednesday 18th May 2022

14.15-14.30 Opening Ceremony

SESSION 1. PROTEIN INTERACTIONS WITH MACROMOLECULES

Chairs: Louise Gourlay (Università di Milano), Valerio Marino (Università di Verona)

14.30-15.00 Adeline Goulet, CNRS Marseille, “Diversity of CRISPR-Cas9 inhibition mechanisms: the tip of an iceberg?"

15.00-15.30 Roberto Contestabile, Università di Roma “La Sapienza”, “Specific and non-specific protein-DNA interactions in transcriptional regulation mediated by MocR-like PLP-dependent factors”

15.30-16.00 Linda Celeste Montemiglio, C.N.R., Istituto di Biologia e Patologia Molecolari, Roma, “Insights on the role of the CD71 iron gate from the cryoEM structure of its complex with ferritin”.

16.00-16.30 Coffee break

Chairs: Nadia Raffaelli (Università Politecnica delle Marche), Riccardo Miggiano (Università del Piemonte Orientale)

16.30-17.00 Stefano Ricagno, Università di Milano, “Ex-vivo structural biology: new insights on systemic amyloidosis” “

17.00-17.30 Loredano Pollegioni, Università dell'Insubria, “Ligand-binding properties of human D-amino acid oxidase: regulation of brain D-serine levels”

17.30-18.00 Stefano Bettati, Università di Parma, “Chasing new targets to fight antimicrobial resistance: interaction of the Staphylococcus aureus hemophore IsdB with human hemoglobin”.

18,00-18.20 Sergio Braglia, PerkinElmer Italia, Milano, “ALPHA and HTRF: homogeneous and quantitative proximity assays to assess protein-protein interaction in pharmacological research”

18.30-19.30 Poster session

19.30 Cocktail

20:15-21:15 Round tables organized by Young Researchers on the following themes:

1. Gender issue in science.
Chairs: Francesca Maffioli (University of Paris), Mariafrancesca Scalise (Università della Calabria), Elisa Maffioli (Università di Milano)

2. Research and Career Skills.
Chairs: Stefano Gianni (Università di Roma, “La Sapienza”), Matteo Becatti (Università di Firenze), Chiara Giacomelli (Università di Pisa)

3. How skills become technologies.
Chairs: Carlo Bonadonna (Fondazione UNIMI), Miggiano Riccardo (Università del Piemonte Orientale), Francesco Marchesani (Università di Parma)


Thursday 19th May 2022

SESSION 2. PROTEIN INTERACTION WITH SMALL LIGANDS

Chairs: Serena Faggiano (Università di Parma), Francesco Marchesani (Università di Parma)

09.00-09.30 Claudiu Supuran, Università di Firenze, “Carbonic anhydrases and their interaction with inhibitors and activators”

09.30-10.00 Roberta Moschini, Università di Pisa, “NADP+/NADPH in human carbonyl reductase 1: from co-reagent to prosthetic group.”

10.00-10.30 Francesca Spyrakis, Università di Torino, “Looking for broad-spectrum inhibitors targeting carbapenemases”

10:30-10:50 Maria Rita Bertoldi,  Università di Verona, “The structural characterization of human aromatic amino acid decarboxylase provides the molecular basis for prediction of severity in AADC deficiency”

10.50-11.15 Coffee break

Chairs: Barbara Cellini (Università di Perugia), Chiara Giacomelli (Università di Pisa)

11.15-11.45 Paolo Pelosi, Austrian Institute of Technology, "Reverse chemical ecology: from carrier proteins to pheromones"

11.45-12.15 Krishna Persaud, University of Manchester, “Advances in Odorant Binding Protein Biosensors”

12.15-12.45  Silvia Garavaglia, Università del Piemonte Orientale, “Targeting human aldehyde dehydrogenase 1A3 in gliomas: drugs and diagnostics development"

12.45-13.15  Antonio Chaves, Università di Milano, "NF-Y ligand fragment search through macromolecular crystallography"

13.15-14.00  Lunch

14.00-15.00 Poster session

SESSION 3. CASE STUDIES FROM PHD STUDENTS

Chairs: Maria Grazia Tozzi (Università di Pisa), Mariafrancesca Scalise (Università della Calabria)

15.00-16.15 5 speakers (12 min)

16.15-16.45 coffee break

16.45-18.00 5 speakers (12 min) 

18.00-19.00 Poster session

20.30 Dinner


Friday 20th May 2022

SESSION 4. METHODS AND MODELS FOR THE CHARACTERIZATION OF PROTEIN INTERACTION

Chairs: Antonio Chaves (Università di Milano), Martina Buonanno (Istituto di Bioistrutture e Bioimmagini - CNR)

09.00-09.30 Gabriele Cruciani, Università di Perugia “BioGPS, a virtual journey through the universe of proteins”

9.30-10.00  Silvio Tosatto, Università di Padova, “Deciphering the structural features of linear interacting peptides in proteins

10.00-10.20  Mario Armelao, SCIEX,  “A way to maximize performance for Protein ID and Quant”

10.20-10.50 coffee break

Chairs: Serena Rinaldo (Università di Roma “La Sapienza”), Matteo Becatti (Università di Firenze)

10.50-11.20 Martin Weik, ESRF, Grenoble, “Structure and dynamics of light-sensitive proteins using time-resolved X-ray scattering and crystallography at synchrotrons and XFELs”

11.20-11.50 Alessandro Paciaroni, Università di Perugia, “Small molecule inhibitors of the SARS-CoV-2 main protease dimerization as potential antivirals”.

11.50-12.20 Leila Birolo, Università di Napoli, “Ancient proteins: from identification to characterization” 

12.20-12.50  Elisa Maffioli, Università di Milano, " SILAC-based quantitative phosphoproteomic analysis on the effect of binding of CCL3L1 to the atypical chemokine receptor ACKR2".

12.50  Concluding remarks

 

Proteine 2022
18|20 May 2022
Pisa, Centro Congressi Benedettine
Piazza S. Paolo a Ripa D'Arno, 16
56125 Pisa PI, Italia

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