Sunday 17th May 2020
14.30-14.45 Opening Ceremony
Session 1. Protein interactions with macromolecules
14.45-15.15 Adeline Goulet, CNRS Marseille “'Diversity of CRISPR-Cas9 inhibition mechanisms: the tip of an iceberg?"
15.15-15.45 Beatrice Vallone, Università di Roma “La Sapienza”, “Insights on the role of the CD71 iron gate from the cryoEM structure of its complex with ferritin”.
15.45-16.15 Stefano Ricagno, Università di Milano “The Cryo-EM structural of cardiac amyloid fibrils from an AL amyloidosis patient”
16.15-16.45 Coffee break
16.45-17.15 Loredano Pollegioni, Università dell'Insubria “Ligand-binding properties of human D-amino acid oxidase: regulation of brain D-serine levels”
17.15-17.45 Stefano Bettati, Università di Parma “Interaction of the Staphylococcus aureus hemophore IsdB with human hemoglobin””
17.45-18.15 Roberto Contestabile, Università di Roma “La Sapienza”, “Specific and non-specific protein-DNA interactions in transcriptional regulation mediated by MocR-like PLP-dependent factors”
18.30-19.30 Poster session
19.30 Cocktail
Monday 18th May 2020
Session 2. Protein interaction with small ligands
09.00-09.45 Claudiu Supuran, Università di Firenze “Carbonic anhydrases and their interaction with inhibitors and activators”
09.45-10.15 Roberta Moschini, Università di Pisa “NADP+/NADPH in human carbonyl reductase 1: from co-reagent to prosthetic group.”
10.15-10.45 Francesca Spyrakis, Università di Torino “Looking for broad-spectrum inhibitors targeting carbapenemases”
10.45-11.15 Coffee break
11.15-11.45 Paolo Pelosi, Austrian Institute of Technology “Improving the specificity of odorant-binding proteins by site-directed mutagenesis”
11.45-12.15 Menico Rizzi, Università del Piemonte Orientale, “Targeting human aldehyde dehydrogenase 1A3 and Mycobacterium tuberculosis IMP dehydrogenase for drug discovery”
12.15-12.45 Antonio Chaves, Università di Milano "NF-Y ligand fragment search through macromolecular crystallography"
12-45-13.45 Lunch
13.45-14.30 Poster session
Session 3. Case studies from PhD students
14.30-16.00 6 speakers (15 min + 5)
16.00-16.30 coffee break
16.30-18.00 6 speakers (15 min + 5)
18.00-19.00 poster session
20.00 Dinner
Tuesday 19th May 2020
Session 4. Methods and Models for the characterization of protein interaction
09.00-09.30 Martin Weik, ESRF, Grenoble “Structure and dynamics of light-sensitive proteins using time-resolved X-ray scattering and crystallography at synchrotrons and XFELs”
9.30-10.00 Gabriele Cruciani, Università di Perugia “BioGPS, a virtual journey through the universe of proteins”
10.00-10.30 Silvio Tosatto, Università di Padova “Deciphering the structural features of linear interacting peptides in proteins"
10.30-11.00 coffee break
11.00-11.30 Alessandro Paciaroni, Università di Perugia “Protein-ligand binding: the role of protein and water dynamics as studied by neutron scattering and molecular dynamics simulations.”
11.30-12.00 Leila Birolo, Università di Napoli “Ancient proteins: from identification to characterization”
12.00-12.30 Elisa Maffioli, Università di Milano “Extracellular environment affects cell differentiation and maturation: a proteomic approach”
12.30 Concluding remarks
