Sunday 17th May 2020

14.30-14.45 Opening Ceremony

Session 1. Protein interactions with macromolecules 

14.45-15.15 Adeline Goulet, CNRS Marseille “'Diversity of CRISPR-Cas9 inhibition mechanisms: the tip of an iceberg?"

15.15-15.45 Beatrice Vallone, Università di Roma “La Sapienza”, “Insights on the role of the CD71 iron gate from the cryoEM structure of its complex with ferritin”.

15.45-16.15  Stefano Ricagno,  Università di Milano “The Cryo-EM structural of cardiac amyloid fibrils from an AL amyloidosis patient”

16.15-16.45 Coffee break

16.45-17.15 Loredano Pollegioni, Università dell'Insubria “Ligand-binding properties of human D-amino acid oxidase: regulation of brain D-serine levels”

17.15-17.45 Stefano Bettati, Università di Parma “Interaction of the Staphylococcus aureus hemophore IsdB with human hemoglobin””

17.45-18.15 Roberto Contestabile, Università di Roma “La Sapienza”, “Specific and non-specific protein-DNA interactions in transcriptional regulation mediated by MocR-like PLP-dependent factors”

18.30-19.30 Poster session

19.30 Cocktail

Monday 18th May 2020

Session 2. Protein interaction with small ligands

09.00-09.45 Claudiu Supuran, Università di Firenze “Carbonic anhydrases and their interaction with inhibitors and activators”

09.45-10.15 Roberta Moschini, Università di Pisa “NADP+/NADPH in human carbonyl reductase 1: from co-reagent to prosthetic group.”

10.15-10.45 Francesca Spyrakis, Università di Torino “Looking for broad-spectrum inhibitors targeting carbapenemases”

10.45-11.15 Coffee break

11.15-11.45  Paolo Pelosi, Austrian Institute of Technology “Improving the specificity of odorant-binding proteins by site-directed mutagenesis”

11.45-12.15  Menico Rizzi, Università del Piemonte Orientale, “Targeting human aldehyde dehydrogenase 1A3 and Mycobacterium tuberculosis IMP dehydrogenase for drug discovery”

12.15-12.45  Antonio Chaves, Università di Milano "NF-Y ligand fragment search through macromolecular crystallography"

12-45-13.45  Lunch

13.45-14.30 Poster session

Session 3.  Case studies from PhD students  

14.30-16.00 6 speakers (15 min + 5)

16.00-16.30 coffee break

16.30-18.00 6 speakers (15 min + 5) 

18.00-19.00 poster session

20.00 Dinner

Tuesday 19th May 2020

Session 4. Methods and Models for the characterization of protein interaction

09.00-09.30 Martin Weik, ESRF, Grenoble “Structure and dynamics of light-sensitive proteins using time-resolved X-ray scattering and crystallography at synchrotrons and XFELs”

9.30-10.00  Gabriele Cruciani, Università di Perugia “BioGPS, a virtual journey through the universe of proteins”

10.00-10.30 Silvio Tosatto, Università di Padova “Deciphering the structural features of linear interacting peptides in proteins"

10.30-11.00 coffee break

11.00-11.30 Alessandro Paciaroni, Università di Perugia “Protein-ligand binding: the role of protein and water dynamics as studied by neutron scattering and molecular dynamics simulations.”

11.30-12.00  Leila Birolo, Università di Napoli “Ancient proteins: from identification to characterization”

12.00-12.30  Elisa Maffioli, Università di Milano “Extracellular environment affects cell differentiation and maturation: a proteomic approach”

12.30  Concluding remarks

Proteine 2020
17|19 May 2020
Pisa, Centro Congressi Benedettine
Piazza S. Paolo a Ripa D'Arno, 16
56125 Pisa PI, Italia

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